BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulation
نویسندگان
چکیده
1 Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka, 563-8577, Japan 2 Institute for Protein Research, Osaka University, Suita, Osaka, 565-0871, Japan 3 Solution Oriented Research for Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama, 332-0012, Japan 4 National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187-8502, Japan 5 Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912 6 Section on Neural Development and Plasticity, NICHD, National Institutes of Health, Bethesda, MD 20892
منابع مشابه
BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts
Brain-derived neurotrophic factor (BDNF) plays an important role in synaptic plasticity but the underlying signaling mechanisms remain unknown. Here, we show that BDNF rapidly recruits full-length TrkB (TrkB-FL) receptor into cholesterol-rich lipid rafts from nonraft regions of neuronal plasma membranes. Translocation of TrkB-FL was blocked by Trk inhibitors, suggesting a role of TrkB tyrosine ...
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Activity-dependent insertion of tyrosine kinase receptor type 2 (TrkB receptor) into the plasma membrane can explain, in part, the preferential effect of brain-derived neurotrophic factor (BDNF) on active neurons; however, the detailed cellular and molecular mechanisms underlying this process are still unclear. In our study, we developed a fluorescence ratiometric assay for surface TrkB recepto...
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تاریخ انتشار 2004